Neurodegenerative Diseases - MINDLab
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Neurodegenerative Diseases

 

Convention relates neurotransmission to brain energy metabolism. Recent revisions involve monoamines in the roles of neurotransmission on short- and long-term potentiation and plasticity, mediated by effects on transcription and translation. Two classes of protein in the outer membrane of mitochondria enter into the response of oxidative metabolism to neuromodulation, the monoamine oxidase enzyme, which yields potentially damaging hydrogen peroxide, and uncoupling proteins 2 and perhaps 3, which may be neuro-protective by maintaining electron flux when oxygen supply and demand are mismatched (Gjedde 2005). We will test the hypotheses that increased rates of monoamine turnover are neurotoxic in Parkinson’s disease, and that excessive decline of oxygen tension in mitochondria initiates apoptosis in Alzheimer’s disease (Rasmussen 2007). Thus, the uncoupling of flow from metabolism is the key to novel theories of neurodegeneration involving the regulation of oxygen tensions in brain tissue. In an effort to study how capillary flow dynamics couple to oxygen metabolism, CFIN scientists developed a theoretical model of oxygen extraction fraction testable by MRI (Jespersen 2008).  

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Revised 7-5-2012