Pain and Perception - MINDLab


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Pain and Perception


Pain and depression are linked by abnormal monoaminergic ascending and descending output from brainstem raphé nuclei, and the network includes cerebral structures that can be traced and monitored (Kupers 2004). We will test the links in healthy volunteers with experimental pain and in patients with depression, functional disorders (fibromyalgia), or neuropathic pain. Monoaminergic activity will be measured by PET and in CSF. We will also test the hypothesis that chronic pain is a result of maladaptive neuroplasticity (Flor 2006), and we will monitor the reorganization by TMS, dorsal column stimulation, cognitive methods, and deep brain stimulation.

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Revised 7-5-2012