Deep Brain Stimulation - MINDLab


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Deep Brain Stimulation


Deep Brain Stimulation (DBS) is an effective and safe therapy for otherwise treatment-resistant disorders such as Parkinson’s disease (PD), essential tremor, chronic pain and dystonia. With whole-brain neuroimaging it is also a powerful tool for unraveling the fundamental mechanisms of human brain function (e.g., Kringelbach, Jenkinson, Green et al 2007). Increasing evidence suggests that the benefits of DBS are due to elevated monoamine. We will investigate the action of DBS by studies in patients and in animal models of PD and neurodegenerative and psychiatric disorders. We will correlate functional and structural neuroimaging by MRI, MEG and PET with the functional and anatomical data from patients and experimental animals, using histology, neurotransmitter levels, gene expressions, and stereological quantification of plastic changes (Bjarkam & Sørensen 2007, Kringelbach 2007).

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Revised 7-5-2012